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This compelling volume examines the evolving landscape of oral cancer research and treatment, providing critical insights into cutting-edge diagnostics, molecular alterations, and therapeutic advancements. With contributions from leading researchers and clinicians, the book presents a comprehensive, multidisciplinary perspective on oral oncology. Key chapters examine the role of salivary epigenetic biomarkers in early detection, the molecular reprogramming of histologically normal tissues adjacent to tumors, and the profound impact of cancer-associated fibroblasts on treatment response. The volume also explores the latest advancements in advanced radiotherapy techniques, including Intensity-Modulated Radiotherapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT), and evaluates outcomes and side effects with a focus on personalized treatment strategies. Importantly, the book addresses the microbial dysbiosis that arises after radiation therapy and its implications for the progression of oral cancer and patient quality of life. Whether you are a clinician, researcher, or healthcare professional, this volume serves as a valuable resource for understanding the molecular intricacies and therapeutic complexities of oral cancer. The book reflects the latest scientific advancements and underscores the importance of precision medicine and interdisciplinary collaboration in improving clinical outcomes for patients worldwide.