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Inflammation is a complex process that involves the body's response to injury or infection. It can be beneficial in the short term, but it can have negative consequences if it becomes chronic. Due to the wide range of bioactive phytochemicals that may have therapeutic qualities, pomelo fruit has been used as a herbal remedy since ancient times, is still in use today, and is probably going to be used in the future. Pomelo can strengthen the immune system, prevent cancer, and improve cardiovascular health. The present study results showed that the extract from pomelo fruits has anti-inflammatory properties. Because of the presence of its active constituents' potential as primary oxidants and ability to scavenge free radicals, pomelo fruit extract significantly inhibited heat-induced albumin denaturation, hemolysis, and hypotonicity of erythrocytes. As a potent anti-inflammatory drug, it can be used to treat a variety of ailments, such as cancer, neurological conditions, aging and inflammation. To develop pomelo fruit as a promising anti-inflammatory therapeutic agent, more work is needed to conduct pre-clinical studies using this fruit in animal models of various diseases.