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This Special Issue explores the critical topic of antimicrobial prescribing, population use, and the global impact of resistance. Bringing together research from leading experts, the articles provide a comprehensive overview of the trends, challenges, and innovations in the fight against antimicrobial resistance (AMR). The studies cover a wide range of subjects, including clinical prescribing behaviors, the societal impact of antibiotic misuse, and strategies for effective antibiotic stewardship. This issue is designed to serve as a valuable resource for researchers, healthcare professionals, and policymakers, offering evidence-based insights to guide the development of better policies and practices aimed at curbing the spread of resistant infections. With its global focus and multidisciplinary approach, this Special Issue offers a timely contribution to one of the most pressing health challenges of our time.