Genetics and Genomics of Candida albicans BiofilmFormation - Nobile, Clarissa
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Candida albicans biofilm formation is a poorlyunderstood, complex biological process withsignificant consequences for human health. In thisthesis, I describe the progress I have made inelucidating the genetic mechanisms of Candidaalbicans biofilm formation using a large-scale genedisruption strategy. The Bcr1-dependent adherenceregulatory pathway that I discovered is pivotal toour understanding of C. albicans biofilm formation.Without the transcription factor Bcr1, named forBiofilm and Cell-wall Regulator, C. albicans cellsare unable to form biofilms, a process that isextremely important to…mehr

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Produktbeschreibung
Candida albicans biofilm formation is a poorlyunderstood, complex biological process withsignificant consequences for human health. In thisthesis, I describe the progress I have made inelucidating the genetic mechanisms of Candidaalbicans biofilm formation using a large-scale genedisruption strategy. The Bcr1-dependent adherenceregulatory pathway that I discovered is pivotal toour understanding of C. albicans biofilm formation.Without the transcription factor Bcr1, named forBiofilm and Cell-wall Regulator, C. albicans cellsare unable to form biofilms, a process that isextremely important to its lifestyle andpathogenicity. Expression analysis indicates thatBcr1 activates cell surface protein and adhesingenes, whose gene products could be used to developnew anti-fungal therapies.
Autorenporträt
Nobile Clarissa§Clarissa Nobile was born in Rome and grew up in NYC. Sheattended Swarthmore College for her undergraduate studies, andColumbia University for graduate school. Her PhD research wasfocused on the study of biofilm development. She has beentrained in microbiology and microbial pathogenesis usingmolecular biology and genetic techniques.