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Human immunodeficiency virus (HIV) pandemic is among the greatest health crises ever faced by humanity. Morbidity and mortality in HIV disease is due to immune suppression leading to life-threatening opportunistic infections (OIs) during the natural course of the disease. However, information available on the effect OIs and coinfections on the immunological responses of HIV sero-positive individuals is limited. This study was aimed at describing the immunological responses of HIV sero-positive with and without some selected infectious diseases.