Production of -lactam Antibiotics through Penicillin V Acylase - Naz, Tooba;Tahir, Arifa
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Semi-synthetic -lactam antibiotics are the largest group of antibiotics used worldwide. Penicillin V Acylase (Cephalosporin acylase) is a crucial enzyme for the development of new enzymatic pathways leading to the production of semi-synthetic cephalosporins. 7-amino desacetoxy cephalosporanic acid (7-ADCA) is an important intermediate in these pathways. Large quantities of this compound are needed, but the traditional production routes are time-consuming, expensive and/or polluting.Pakistan being an agricultural country has potential resources of biomass for their exploitation in the manufacture of cell biomass, enzymes or microbial metabolites.…mehr

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Produktbeschreibung
Semi-synthetic -lactam antibiotics are the largest group of antibiotics used worldwide. Penicillin V Acylase (Cephalosporin acylase) is a crucial enzyme for the development of new enzymatic pathways leading to the production of semi-synthetic cephalosporins. 7-amino desacetoxy cephalosporanic acid (7-ADCA) is an important intermediate in these pathways. Large quantities of this compound are needed, but the traditional production routes are time-consuming, expensive and/or polluting.Pakistan being an agricultural country has potential resources of biomass for their exploitation in the manufacture of cell biomass, enzymes or microbial metabolites.
Autorenporträt
I am an environmentalist by profession. My area of specialization is Industrial Microbiology. All research focus is on the production of Beta-lactam acylase by an efficient and environmentally benign process. Thanks to Allah Almighty and my loving Parents and Supervisor who help me to fulfill this task.