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Diabetes mellitus is a disease in which the body is unable to produce or unable to properly use and store glucose (a form of sugar). Glucose backs up in the bloodstream causing ones blood glucose or "sugar" to raise too high. The diabetes Mellitus having their own historical aspect in 1552 B.C. earliest known of diabetes mentioned on 3rd dynasty Egyptian papyrus by physician mention polyuria (frequent Urination) as a symptom. It has some important landmarks as 1869, German medical student Pual Langerhance discovered that pancreas contains two distinct groups of cells-Acinar cells and islets (cells that are clustered in islands). Quantitative Structure Activity Relationship (QSAR) studies represent the non-experimental part of drug design, including investigation of both structure-activity and structure-property relationship. This is an intellectual exercise comprising assembling, manipulating and inspecting information got from physical, chemical and biological experiments and correlating these to biological activity.