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This publication compiles key learnings from ADB-supported COVID-19 vaccination programs in seven Southeast Asian countries and analyzes the importance of logistics, health digitalization, and public-private partnerships to the region's pandemic response. Drawing on interviews with leading public health practitioners, the publication details the experiences of Cambodia, Indonesia, the Lao People's Democratic Republic, the Philippines, Thailand, Timor-Leste, and Viet Nam. Its recommendations include making sustained investments in health, driving strong stakeholder partnerships, and building robust digital infrastructure to help countries both prepare for future pandemics and strengthen overall regional health security.