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The primary goal of medicinal chemistry is to comprehend the molecular causes of a medication's or drug candidate's action. The idea of favored scaffolds is one of the tactics and methods that could be employed to accomplish the molecular design of novel structures. Several medicinally significant scaffolds, including arylidines, azetidinones, benzylidineacetophenone, oxothiazolidine and isoxazole are covered in this book's opening chapter.