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The purpose of the present research work was to carryout clinical study on primary dysmenorrhoea to comparatively examine the coded herbal drug formulation with authentic allopathic medicines. A random controlled clinical trial was conducted to compare the effectiveness and safety of coded herbal medicinal treatment Dysmo-off with Voren. In this study clinical trial statistical data so generated and the results conclusively obtained proved that coded herbal medicine Dysmo-off had a significant greater improvement in combined symptoms of dysmenorrhoea compared with those of Voren treatment so the null hypothesis was strongly rejected on the basis of p value calculated by chi- square test in both treatment groups. The conclusion deduced that Dysmo-off is effective and safe for the treatment of dysmenorrhoea when compared with Voren.