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We are pleased to announce this Special Issue of Molecules that is dedicated to Prof. Carlos Gutiérrez-Merino, honoring his outstanding contributions to molecular science, biochemistry, and related disciplines. This commemorative Special Issue brings together the following topics: Ca2+-ATPase pumps, plasma membrane L-type calcium channels, microsomal cytochrome P450s reductase, plasma membrane cytochrome b5 reductase, metalloproteins, glycogen phosphorylase, natural antioxidants, Aβ amyloid peptides, and functional characterization of the neuronal plasma membrane nanodomains.