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This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how…mehr
This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
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Autorenporträt
DARRELL R. BOVERHOF, PhD, is a Senior Toxicology Specialist at The Dow Chemical Company where he leads research programs on respiratory allergy and sensitization, nanotoxicology, and toxicogenomics. Dr. Boverhof has authored or coauthored numerous peer-reviewed publications, review articles, and book chapters in the area of toxicogenomics and serves on the editorial board of the journal Toxicological Sciences. B. BHASKAR GOLLAPUDI, PhD, is the Scientific Director of Mammalian Toxicology at The Dow Chemical Company's Global Toxicology & Environmental Research Laboratory. Dr. Gollapudi has authored or co-authored more than 80 scientific publications. He is an Associate Editor of the journal Toxicological Sciences and is currently serving as an adjunct Associate Professor of Toxicology in the Department of Public Health at the University of Michigan.
Inhaltsangabe
PREFACE ix CONTRIBUTORS xi 1 TOXICOLOGY, "OMICS" TECHNOLOGIES, AND TOXICOGENOMICS: A PRIMER 1 Darrell R. Boverhof and B. Bhaskar Gollapudi 2 INTRODUCTION TO HUMAN HEALTH RISK ASSESSMENT 13 Irene Baskerville-Abraham, Alison Willis, Bernard Gadagbui, and Lynne T. Haber 3 PRACTICAL CONSIDERATIONS FOR THE APPLICATION OF TOXICOGENOMICS TO RISK ASSESSMENT: EARLY EXPERIENCE, CURRENT DRIVERS, AND A PATH FORWARD 41 Darrell R. Boverhof, David R. Geter, B. Bhaskar Gollapudi, and Heli Hollnagel 4 APPROACHES AND PRACTICAL CONSIDERATIONS FOR THE ANALYSIS OF TOXICOGENOMICS DATA 65 Zhenqiang Su, Hong Fang, Weida Tong, Huixiao Hong, Roger Perkins, and Leming Shi 5 GENOMICS IN IDENTIFYING MUTAGENIC MODE OF ACTION IN CARCINOGENESIS 81 Jiri Aubrecht and Ebru Caba 6 APPLICATION OF GENOMICS FOR PREDICTING AND UNDERSTANDING THE MODE OF ACTION FOR NONGENOTOXIC CARCINOGENS 99 Mark R. Fielden 7 GENOMICS IN CHARACTERIZING ENDOCRINE TOXICITY 117 Jorge M. Naciff and George P. Daston 8 STUDYING ORGAN-SPECIFIC TOXICITY USING GENE-EXPRESSION PROFILING 147 M. Ann Mongan and Hisham K. Hamadeh 9 TOXICOGENOMIC STUDIES IN HUMAN POPULATIONS 177 Cliona M. McHale, Luoping Zhang, Alan E. Hubbard, and Martyn T. Smith 10 TOXICOGENOMICS APPLIED TO ECOLOGICAL RISK ASSESSMENT 207 Daniel L. Villeneuve, Dalma Martinovi¿c, and Gerald T. Ankley 11 ANALYSIS OF TRANSCRIPTOMIC DOSE-RESPONSE DATA FOR TOXICOLOGY AND RISK ASSESSMENT 237 Russell S. Thomas, Longlong Yang, Harvey J. Clewell, and Melvin E. Andersen 12 TOXICOGENOMICS AS A TOOL FOR VALIDATING ANIMAL TO HUMAN EXTRAPOLATIONS IN CHEMICAL RISK ASSESSMENT: CONCEPTS, APPLICATIONS, AND CHALLENGES 251 Alan Dombkowski and J. Craig Rowlands 13 TOXICOGENOMICS AND ANIMAL ALTERNATIVES 267 Anne S. Kienhuis, Joost H. M. van Delft, and Jos C. S. Kleinjans 14 TOXICOGENOMICS AND THE REGULATORY FRAMEWORK 293 Kathryn Gallagher, Federico M. Goodsaid, David J. Dix, Susan Y. Euling, Melissa Kramer, Nancy E. McCarroll, Julian R. Preston, Philip G. Sayre, Banalata Sen, Douglas C. Wolf, and William H. Benson 15 STANDARDIZATION OF GENE-EXPRESSION INFORMATION FOR THE SAFETY EVALUATION: ACTIVITIES IN JAPAN 323 Ken-ichi Aisaki and Jun Kanno 16 APPLYING TRANSCRIPTIONAL PROFILING IN DRUG SAFETY EVALUATION 331 Lois D. Lehman-McKeeman and William R. Foster 17 REFRAMING THE RISK ASSESSMENT PARADIGM: TOWARD A SYSTEMS BIOLOGY APPROACH 349 Sarah N. Campion and Kim Boekelheide INDEX 357
PREFACE ix CONTRIBUTORS xi 1 TOXICOLOGY, "OMICS" TECHNOLOGIES, AND TOXICOGENOMICS: A PRIMER 1 Darrell R. Boverhof and B. Bhaskar Gollapudi 2 INTRODUCTION TO HUMAN HEALTH RISK ASSESSMENT 13 Irene Baskerville-Abraham, Alison Willis, Bernard Gadagbui, and Lynne T. Haber 3 PRACTICAL CONSIDERATIONS FOR THE APPLICATION OF TOXICOGENOMICS TO RISK ASSESSMENT: EARLY EXPERIENCE, CURRENT DRIVERS, AND A PATH FORWARD 41 Darrell R. Boverhof, David R. Geter, B. Bhaskar Gollapudi, and Heli Hollnagel 4 APPROACHES AND PRACTICAL CONSIDERATIONS FOR THE ANALYSIS OF TOXICOGENOMICS DATA 65 Zhenqiang Su, Hong Fang, Weida Tong, Huixiao Hong, Roger Perkins, and Leming Shi 5 GENOMICS IN IDENTIFYING MUTAGENIC MODE OF ACTION IN CARCINOGENESIS 81 Jiri Aubrecht and Ebru Caba 6 APPLICATION OF GENOMICS FOR PREDICTING AND UNDERSTANDING THE MODE OF ACTION FOR NONGENOTOXIC CARCINOGENS 99 Mark R. Fielden 7 GENOMICS IN CHARACTERIZING ENDOCRINE TOXICITY 117 Jorge M. Naciff and George P. Daston 8 STUDYING ORGAN-SPECIFIC TOXICITY USING GENE-EXPRESSION PROFILING 147 M. Ann Mongan and Hisham K. Hamadeh 9 TOXICOGENOMIC STUDIES IN HUMAN POPULATIONS 177 Cliona M. McHale, Luoping Zhang, Alan E. Hubbard, and Martyn T. Smith 10 TOXICOGENOMICS APPLIED TO ECOLOGICAL RISK ASSESSMENT 207 Daniel L. Villeneuve, Dalma Martinovi¿c, and Gerald T. Ankley 11 ANALYSIS OF TRANSCRIPTOMIC DOSE-RESPONSE DATA FOR TOXICOLOGY AND RISK ASSESSMENT 237 Russell S. Thomas, Longlong Yang, Harvey J. Clewell, and Melvin E. Andersen 12 TOXICOGENOMICS AS A TOOL FOR VALIDATING ANIMAL TO HUMAN EXTRAPOLATIONS IN CHEMICAL RISK ASSESSMENT: CONCEPTS, APPLICATIONS, AND CHALLENGES 251 Alan Dombkowski and J. Craig Rowlands 13 TOXICOGENOMICS AND ANIMAL ALTERNATIVES 267 Anne S. Kienhuis, Joost H. M. van Delft, and Jos C. S. Kleinjans 14 TOXICOGENOMICS AND THE REGULATORY FRAMEWORK 293 Kathryn Gallagher, Federico M. Goodsaid, David J. Dix, Susan Y. Euling, Melissa Kramer, Nancy E. McCarroll, Julian R. Preston, Philip G. Sayre, Banalata Sen, Douglas C. Wolf, and William H. Benson 15 STANDARDIZATION OF GENE-EXPRESSION INFORMATION FOR THE SAFETY EVALUATION: ACTIVITIES IN JAPAN 323 Ken-ichi Aisaki and Jun Kanno 16 APPLYING TRANSCRIPTIONAL PROFILING IN DRUG SAFETY EVALUATION 331 Lois D. Lehman-McKeeman and William R. Foster 17 REFRAMING THE RISK ASSESSMENT PARADIGM: TOWARD A SYSTEMS BIOLOGY APPROACH 349 Sarah N. Campion and Kim Boekelheide INDEX 357
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