J. Kelley

Cytokines of the Lung (eBook, PDF)

• Format: PDF

Produktbeschreibung

Focusing on all the major cytokine families, this reference book provides coverage of cytokine regulatory processes in the lung and other tissues and comprehensive descriptions of cytokine functions specific to the lung.;Discussing the diverse cytokine-binding proteins and the role of cytokines in tissue injury and repair processes and extracellular matrix regulations, the book supplies information on amino acid structure and gene regulatory sequences, examines the receptor biology of individual cytokines, illustrates cytokine interactions with their cognate receptors and surveys the phenotypic effects of individual cytokines on target cells. With over 2700 literature citations and figures, this book is a resource for pulmonologists, physiologists, immunologists, cell and molecular biologists, environmental toxicologists, oncologists, and graduate-level and medical school students in these disciplines.

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 664
• Erscheinungstermin: 19. April 2022
• Englisch
• ISBN-13: 9781000105643
• Artikelnr.: 63775795

Autorenporträt

Jason Kelley is Professor of Medicine at the University of Vermont College of Medicine, Burlington, and Director of the Medical Intensive Care Unit, Medical Center Hospital of \fermont, Burlington. He is the author or coauthor of more than 60 professional papers, reports, and abstracts that reflect his research interests in cytokines and pulmonary disease. Dr. Kelley is a member of the American Society for Cell Biology, the Biochemical Society, the American Thoracic Society, and the American Association for the Advancement of Science, among other organizations. He received the A.B. degree (1966) in physics from Harvard University, Cambridge, Massachusetts, and the M.D. degree (1972) from the University of Texas Southwestern Medical School at Dallas.

Inhaltsangabe

Introduction
Preface
Contributors
Part I MITOGENIC CYTOKINES
1. Platelet
Derived Growth Factor /James P. Fabisiak and Jason Kelley
I. Introduction
II. Protein Structure
III. Gene Structure, Organization, and Processing
IV. PDGF Receptors
V. Biological Properties of PDGFs
VI. Cellular Sources of PDGF
VII. Regulation of PDGF
VIII. PDGF in Lung Disease
IX. Conclusions
References
2. Fibroblast Growth Factors /David Moscatelli
I. Introduction
IL History of FGFs
III. Structural Properties
IV. FGF Receptors
V. Interaction with Extracellular Matrix
VI. Biological Properties
VIL The Role of FGFs in Tumor Formation
VIII. FGFs in Lung Biology
References
3. Insulin
Like Growth Factors /Alan D. Stiles, Billie M. Moats
Staats, and George Z. Retsch
Bogart
I. Introduction
II. IGF Peptides
III. IGF Genes and Transcripts
IV. IGF Receptors
V. IGF
Binding Proteins
VI. Actions of IGFs
VIL Role of IGFs in Fetal Growth
VIII. Role of IGFs in Postnatal Growth
IX. IGFs and Lung
X. Summary
References
4. Transforming Growth Factor
,8 /Jason Kelley
I. Introduction
II. The TGF
ß Family of Proteins
III. Biosynthesis of TGF
ß
IV. Gene Structure of TGF
,Bs
V. Control of TGF
ß Gene Expression
VI. Autoinduction of TGF
ß Gene Expression
VII. Activation of TGF
ß Protein
VIII. Receptors for TGF
ß
IX. Signaling Pathways for TGF
ß
X. TGF
ß as a Mitogen
XL Antiproliferative Effects of TGF
ß
XII. TGF
ß and Extracellular Matrix
XIII. Interactions Between TGF
ß and Other Cytokines
XIV. TGF
ß and the Immune System
xv. TGF
ß in Monocyte
Macrophages, Granulocytes, and Mast Cells
XVI. TGF
ß in Fibroblasts
XVII. Assays for TGF
ß
XVIII. TGF
ß in Lung
XIX. TGF
ß in Remodeling and Fibrosis
xx. Future Directions
References
5. Transforming Growth Factor
a and Epidermal Growth Factor /David K. Madtes
I. Introduction
II. The Growth Factor Pr