Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology (eBook, ePUB)

Redaktion: Grumezescu, Alexandru Mihai

• Format: ePub

Produktbeschreibung

Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed.

This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized.

• Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products
• Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years
• Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 696
• Erscheinungstermin: 11. Dezember 2017
• Englisch
• ISBN-13: 9780128136300
• Artikelnr.: 50405725

Inhaltsangabe

1. Fabrication of polymeric core-shell nanostructures
2. Emulsification-diffusion method to obtain polymeric nanoparticles: two
decades of research
3. Tools and Techniques for the optimized synthesis, reproducibility and
scale up of desired nanostructures from plant derived material and their
role in pharmaceutical properties
4. Scale up of biopharmaceuticals production
5. Physicochemical and morphological characterization of pharmaceutical
nanocarriers and mathematical modelling of drug encapsulation/release mass
transfer processes
6. Biopharmaceutics and pharmacokinetics of multifunctional nanoparticles
7. Technological delivery systems to improve biopharmaceutical properties
8. From physicochemically stable nanocarriers to targeted drug delivery:
in-vivo pharmacokinetic, pharmacodynamic and biodistribution studies
9. Sterile dosage forms loaded nanosystems for parenteral, nasal, pulmonary
and ocular administration
10. Quantitative Characterization of Targeted Nanoparticulate Formulations
for Prediction of Clinical Efficacy
11. Analytical tools for reliable in vitro and in vivo performance testing
of drug nanocrystals
12. Application of one-step affinity purification of drug-binding proteins
with practical magnetic nanoparticles to drug discovery
13. Molecularly Imprinted Polymers as Separation Tools
14. Detection of DNA damage induced by nanomaterials
15. Pharmacological usage of an enzyme inhibitor - a selective inhibitor of
3-mercaptopyruvate sulfurtransferase reaction intermediate to control
generation of polysulfide
16. Regulatory Consideration in Nanotechnology Based Drug Products