New Opioid Receptor Modulators and Agonists (eBook, ePUB)

Relevance for Pain and Opioid Use Disorder Management
Redaktion: Kaye MD; Edwards, Scott

• Format: ePub

Produktbeschreibung

New Opioid Receptor Modulators and Agonists: Relevance for Pain and Opioid Use Disorder Management provides crucial insights for developing ideal synthetic opioids. It discusses opioid receptor modulators' structures and mechanisms, and their potential applications in treating pain, misuse, and addiction. This comprehensive resource delves into current research and therapeutic development avenues regarding opioid receptors' structure and function. Sections cover the rationale for developing allosteric modulators, identifying allosteric sites on opioid receptors, and the modulators' modes of action. Readers will gain a thorough understanding of creating ideal synthetic opioids and potential future research.It also explores pharmacogenomics, precision medicine, and various syndromes and comorbidities linked to opioid use. Lastly, it reviews novel synthetic opioids and the risks of misuse and overdose. - Provides an in-depth look at opioid receptor system and novel aspects of opioid pharmacology< - Discusses novel synthetic opioid clinical considerations - Examines synthetic opioid misuse and pain management

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 300
• Erscheinungstermin: 1. Oktober 2025
• Englisch
• ISBN-13: 9780443265051
• Artikelnr.: 75543481

Inhaltsangabe

The Opioid Receptor System and Novel Aspects of Opioid Pharmacology
1. Making Sense of the Complexities of Opioid Receptor Function: Evolving
Appreciation of Opioid Receptor Classification and Basic Characteristics
2. Allostery at Opioid Receptors: Modulation with Small Molecule Ligands,
Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid
Receptor Signaling as a Potential Target for Pain Management
3. Opioid Agonist and Antagonist Pharmacology: Phenylpiperidines, Tramadol,
Buprenoprhine, Methadone, and Codeine Derivatives Synthetic Opioid Clinical
Considerations
4. Pharmacogenomics/Precision Medicine: Opioid-related Interactions and
Metabolism Considerations
5. Opioid-associated Syndromes and Comorbidities
6. Opioid-induced Hyperalgesia
7. Drug Facts: Novel Synthetic Opioids Synthetic Opioid Misuse and Pain
Management
8. Roots of the Opioid Crisis: Description of the Four Waves of the Opioid
Epidemic
9. Opioids and Risk of Dependency: Neurobiology of Opioid Use Disorder
10. Opioids and Risk of Dependency: Responsibilities of Healthcare Workers,
Manufacturers, and Pharmacists
11. CDC Guidelines for Chronic Pain in the Adult, Including Newer
Guidelines Against Co-prescription with Benzodiazepines.
12. Commonly Prescribed Opioids and Adjuvants in Acute and Chronic Pain
Management
13. Clinical Considerations of Commonly Prescribed Medications in Substance
Abuse Management (e.g., buprenorphine (how is it prescribed); methadone
(concerns over prolonged QT EKG prior to administration; urine drug screens
14. The Role of Naltrexone and Novel Preparations for Substance Abuse and
Pain Management
15. Palliative Care for Cancer and Considerations for Opioid-mediated
Suppression of Natural Killer Cells
16. Abuse Deterrent Formulations of Opioids and Opioid Vaccines
17. Opioid Detoxification Techniques