Pharmacokinetics of Drugs (eBook, PDF)

Redaktion: Welling, Peter G.; Balant, Luc P.

• Format: PDF

Produktbeschreibung

A compilation of researchers' experience in the areas of bioanalysis, pharmacokinetics, and drug metabolism, to present an up-to-date and comprehensive treatise on the application of these and related technologies in drug discovery, development, and clinical use. Contents cover descriptions of analytical methods, in vitro metabolism technology and membrane transport, reappraisal of classical pharmacokinetic problems, and the time course of drug action. The book concludes with a description of PET and imaging methods in pharmacokinetics and an appendix containing a critical appraisal of computer methods and pharmacokinetic software available for PCs.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 537
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9783642786808
• Artikelnr.: 53386737

Inhaltsangabe

A. Introduction.- 1 Role of Pharmacokinetics in Drug Discovery and Development.- B. Analytical Methods.- 2 Contemporary Aspects of Radioimmunoassay Development for Drug Analysis.- 3 Mass Spectrometry in Drug Disposition and Pharmacokinetics.- 4 Analytical Methods for Biotechnology Products.- C. In Vitro Methods-Protein and Tissue Binding.- 5 Metabolism: Scaling-up from In Vitro to Organ and Whole Body.- 6 Gastrointestinal Transport of Peptide and Protein Drugs and Prodrugs.- D. Classical Problems.- 7 Stereoselectivity in Metabolic Reactions of Toxication and Detoxication.- 8 Interethnic Differences in Drug Disposition and Response: Relevance for Drug Development, Licensing, and Registration.- 9 Clinical Relevance of Pharmacogenetics.- 10 Role of Environmental Factors in the Pharmacokinetics of Drugs: Considerations with Respect to Animal Models, P-450 Enzymes, and Probe Drugs.- 11 Time Course of Drug Effect.- E. Future Trends in Pharmacokinetics.- 12 Biotechnology Products.- 13 Peptide and Protein Drugs.- 14 Toxicokinetics.- 15 The Population Approach: Rationale, Methods, and Applications in Clinical Pharmacology and Drug Development.- F. Impact of New Methods on Pharmacokinetics.- 16 Contribution of Positron Emission Tomography to Pharmacokinetic Studies.- 17 In Vivo Imaging in Drug Discovery and Design.- G. Appendix.- 18 Considerations on Data Analysis Using Computer Methods and Currently Available Software for Personal Computers.