This manual describes the principles behind various types of experiments on biological samples using sychrotron radiation or neutrons, and it provides the technical understanding needed for interpreting the data collected.
This manual describes the principles behind various types of experiments on biological samples using sychrotron radiation or neutrons, and it provides the technical understanding needed for interpreting the data collected.
* Foreword * Introduction * Challenges in structural molecular biology: genomics in three dimensions * Data collection and reduction methods * Experimental phase determination of structure factors phases in biocrystallography * Electron density - calculation, modification and interpretation * Neutron crystallography of biological molecules * Reactions in crystals and time-resolved crystallography * Local structure of metalloproteins at atomic resolution by XAFS * Molecular dynamics * Inelastic and Quasielastic neutron scattering: complementarity with biomolecular simulation * Diffuse X-ray scattering from molecular crystals * Small-angle X-ray scattering by solutions of biological macromolecules * Small angle neutron scattering * Structure, dynamic and function of the proton pump bacteriorhodopsin * Fibre and muscle diffraction * Biological spectroscopy using low energy (VUV/UV) synchrotron radiation * X-ray microscopy * Crystallography of viruses and very large macromolecules * The quest for high resolution phasing for large macromolecular assemblies exhibiting severe non-isomorphism, extreme beam sensitivity and no internal symmetry * Nuclear spin contrast variation studies on macromolecular complexes
* Foreword * Introduction * Challenges in structural molecular biology: genomics in three dimensions * Data collection and reduction methods * Experimental phase determination of structure factors phases in biocrystallography * Electron density - calculation, modification and interpretation * Neutron crystallography of biological molecules * Reactions in crystals and time-resolved crystallography * Local structure of metalloproteins at atomic resolution by XAFS * Molecular dynamics * Inelastic and Quasielastic neutron scattering: complementarity with biomolecular simulation * Diffuse X-ray scattering from molecular crystals * Small-angle X-ray scattering by solutions of biological macromolecules * Small angle neutron scattering * Structure, dynamic and function of the proton pump bacteriorhodopsin * Fibre and muscle diffraction * Biological spectroscopy using low energy (VUV/UV) synchrotron radiation * X-ray microscopy * Crystallography of viruses and very large macromolecules * The quest for high resolution phasing for large macromolecular assemblies exhibiting severe non-isomorphism, extreme beam sensitivity and no internal symmetry * Nuclear spin contrast variation studies on macromolecular complexes
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