This book presents current methods to perform informative analyses using real and illustrative data with established bioinformatics tools, and guides the reader through the use of publicly available data. The code and datasets, as well as solutions will be accessible online to help readers reproduce all results and figures in the book.
This book presents current methods to perform informative analyses using real and illustrative data with established bioinformatics tools, and guides the reader through the use of publicly available data. The code and datasets, as well as solutions will be accessible online to help readers reproduce all results and figures in the book.
Juan R. González is an Associate Research Professor leading the Bioinformatics Research Group in Epidemiology at Barcelona Institute for Global Health. He has published extensively on methods and bioinformatics tools to detect structural variants from genomic data and to perform different types of omic association studies. Dr. González is the author of a large number of R and Bioconductor packages including state-of-the-art libraries such as SNPassoc or MAD that have been used to discover new susceptibility genetic factor for complex diseases. Alejandro Caceres is a Senior Statistician in the Bioinformatics Research Group in Epidemiology at Barcelona Institute for Global Health. He has large experience in developing new statistical methods to exploit genomic, transcriptomic and epigenomic data obtained from public repositories. Dr. Cáceres is the author of several R and Bioconductor packages that have been used, for instance, to study the role of polymorphic genomic inversions in complex diseases or to investigate how the downregulation of chromosome Y may affect age-related diseases.
Inhaltsangabe
1 Introduction 2 Case examples 3 Dealing with omic data in Bioconductor 4 Genetic association studies 5 Genomic variant studies 6 Adressing batch effects 7 Transcriptomic studies 8 Epigenomic studies 9 Exposomic analysis 10 Enrichment analysis 11 Multiomic data analysis
