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This book traces the foundations of the beta-lactam family in modern antibiotic therapy, while exploring the dynamics and extent of bacterial resistance that threatens their efficacy. Bringing together history, mechanisms of action and prescription strategies, it details the main mechanisms of enzymatic and non-enzymatic resistance, in enterobacteria and Gram-positive bacteria, and outlines contemporary epidemiological and clinical issues. Innovative therapeutic approaches, including phage therapy and the One Health approach, are discussed as complementary solutions to counter bacterial…mehr

Produktbeschreibung
This book traces the foundations of the beta-lactam family in modern antibiotic therapy, while exploring the dynamics and extent of bacterial resistance that threatens their efficacy. Bringing together history, mechanisms of action and prescription strategies, it details the main mechanisms of enzymatic and non-enzymatic resistance, in enterobacteria and Gram-positive bacteria, and outlines contemporary epidemiological and clinical issues. Innovative therapeutic approaches, including phage therapy and the One Health approach, are discussed as complementary solutions to counter bacterial multidrug resistance and limit the environmental and zoonotic spread of resistance genes. The book is aimed at clinicians, researchers, pharmacists and decision-makers, offering recommendations for the rational use of beta-lactam antibiotics, increased surveillance and the strengthening of collaborative actions between human, veterinary and environmental medicine, in order to sustainably preserve this cornerstone of the anti-infectious arsenal.
Autorenporträt
Doutoramento em microbiologia aplicada pela Universidade de 20 de agosto de 1955-Skikda, membro do Laboratoire de Recherche sur les Interactions, la Biodiversité, les Écosystèmes et la Biotechnologie. Seis anos de experiência como docente a tempo parcial, ensinando microbiologia geral e controlo microbiológico dos géneros alimentícios.