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In this collection of manuscripts, the assessments of the success of information systems used in the e-government applications and medical sector by some models have been presented. The book consists of five chapters: in the first two chapters, HIS, governmental institutions (related laws and regulations), and e-prescription systems, which are the fundamental components of the medical sector in Turkey, has been investigated. In the third chapter, the clustering analysis of the clinics in the medical faculties of the universities has been presented. In the fourth and fifth chapters, e-government applications and a specific example of it have been studied.