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As a result of a comprehensive study based on the use of various physiological and biochemical indicators using modern mathematical methods of analysis, a medical and biological basis has been developed for assessing the influence of eco-pathogenic environmental factors on the functional state of the human body with prediction of varying degrees of its stress and the adequacy of adaptive reactions. The results of the complex study provided a scientific basis for assessing and predicting pre-nosological conditions with the development of targeted preventive measures to prevent the depletion of the body's adaptive capabilities under the influence of a combination of ecopathogenic factors and adequate adjustment of methodological approaches to normalizing the functional reserves of the body and the complete restoration of its health.