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This Special Issue, "Advances in Flotation of Copper, Lead and Zinc Minerals," presents recent developments in the flotation of non-ferrous base metals, addressing the key challenges posed by increasingly complex and lower-grade ores. The ten research contributions compiled here span from the molecular-level design of novel flotation reagents-such as selective collectors and depressants-to the understanding of interfacial mechanisms through advanced analytical and computational tools. The topics include the role of metal ions, the effects of pH, reagent synergy, flotation hydrodynamics, and ore-specific process design. The studies also integrate process mineralogy with flowsheet optimization for challenging ore types. This reprint offers valuable insights into sustainable, efficient, and selective flotation strategies for Cu-Pb-Zn systems, reflecting the convergence of fundamental science and industrial applications.