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This book provides a comprehensive exploration of cutting-edge strategies in the diagnosis and treatment of HER2-positive brain metastases, a critical challenge in oncology. The book highlights the integration of molecular imaging, targeted drug delivery, nanomedicine, and personalized therapeutic approaches to improve patient survival and quality of life. It examines the biological mechanisms driving HER2 signaling in brain tumors, while emphasizing translational research and clinical applications of theranostic platforms. Multidisciplinary perspectives are presented, bridging oncology, radiology, pharmacology, and neurosurgery to create a cohesive understanding of precision theranostics. Designed for researchers, clinicians, and graduate students, the book serves as both a scientific reference and a practical guide to novel interventions that combine diagnostics with therapeutics. It underscores the potential of individualized medicine in overcoming therapeutic resistance and advancing the future of neuro-oncology.