Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work i
n Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
Inhaltsangabe
Discovery of Activation-Induced Cytidine Deaminase, the Engraver of Antibody Memory DNA Deamination in Immunity: Aid in the Context of Its Apobec Relatives The Role of Activation Induced Deaminase in Antibody Diversification and Chromosome Translocations Targeting of AID-mediated Sequence Diversification by cis-acting Determinants AID-initiated Purposeful Mutations in Immunoglobulin Genes Post-translational AID Regulation Beyond SHM and CSR: AID and Related Cytidine Deaminases in the Host Response to Viral Infection AID expression and tumorigenesis Pathophysiology of B Cell Intrinsic Immunoglobulin Class Switch Recombination Deficiencies
Discovery of Activation-Induced Cytidine Deaminase, the Engraver of Antibody Memory DNA Deamination in Immunity: Aid in the Context of Its Apobec Relatives The Role of Activation Induced Deaminase in Antibody Diversification and Chromosome Translocations Targeting of AID-mediated Sequence Diversification by cis-acting Determinants AID-initiated Purposeful Mutations in Immunoglobulin Genes Post-translational AID Regulation Beyond SHM and CSR: AID and Related Cytidine Deaminases in the Host Response to Viral Infection AID expression and tumorigenesis Pathophysiology of B Cell Intrinsic Immunoglobulin Class Switch Recombination Deficiencies
Es gelten unsere Allgemeinen Geschäftsbedingungen: www.buecher.de/agb
Impressum
www.buecher.de ist ein Internetauftritt der buecher.de internetstores GmbH
Geschäftsführung: Monica Sawhney | Roland Kölbl | Günter Hilger
Sitz der Gesellschaft: Batheyer Straße 115 - 117, 58099 Hagen
Postanschrift: Bürgermeister-Wegele-Str. 12, 86167 Augsburg
Amtsgericht Hagen HRB 13257
Steuernummer: 321/5800/1497
USt-IdNr: DE450055826