Reflecting the growth in the field and the heightened focus on select areas, this volume updates a classic text and captures the current state and future direction of technologies in combinatorial chemistry. Topics discussed include: properties of solid-phase samples, analytical studies targeted to understand these properties, and resin swelling. It also covers Fourier transform infrared techniques, on-support mass spectrometry, nuclear magnetic resonance methods used in the reaction optimization stage, and combinatorial library analysis using spectrophotometric, fluorometric, and other methods.…mehr
Reflecting the growth in the field and the heightened focus on select areas, this volume updates a classic text and captures the current state and future direction of technologies in combinatorial chemistry. Topics discussed include: properties of solid-phase samples, analytical studies targeted to understand these properties, and resin swelling. It also covers Fourier transform infrared techniques, on-support mass spectrometry, nuclear magnetic resonance methods used in the reaction optimization stage, and combinatorial library analysis using spectrophotometric, fluorometric, and other methods.
Bing Yan received his Ph.D. from Columbia University with Koji Nakanishi in 1990. He is a faculty member at the Department of Chemical Biology and Therapeutics at St. Jude Children's Research Hospital in Memphis, Tennessee, and an adjunct professor at Shandong University. Bin Zhang received his Ph.D. from the Institute of Inorganic and Analytical Chemistry and Radiochemistry at Saarland University (Germany) with Professor Doctor Horst P. Beck in 2003. He is an associate professor of analytical chemistry in the School of Chemistry and Chemical Engineering at Shandong University, China.
Inhaltsangabe
Analytical issues in combinatorial chemistry. An examination of the analytical sample resin support. Solid-phase reaction optimization using FTIR. Reaction optimization using MS and NMR methods. Reaction optimization using spectrophotometric and other methods. Quality control of combinatorial libraries. High-throughput purification. Final Thoughts and Future Perspectives.
Analytical issues in combinatorial chemistry. An examination of the analytical sample resin support. Solid-phase reaction optimization using FTIR. Reaction optimization using MS and NMR methods. Reaction optimization using spectrophotometric and other methods. Quality control of combinatorial libraries. High-throughput purification. Final Thoughts and Future Perspectives.
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