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Numerical simulations were carried out on two-phase Taylor flow and thermal characteristics in uniform and wavy circular microchannels. The variation in droplet shape and pressure distribution in a unit cell have been discussed for uniform and wavy microchannels. An isothermal wall boundary was applied to the heating section to explore heat transfer characteristics. Results show that two-phase in wavy channels enhances the Nusselt number up to 130% in comparison with liquid-only flows and up to 6% augmentation in comparison with the two-phase flow in uniform circular microchannel.