Antibacterial activity of Celecoxib - Allal, Farida;KOURIMI, Khouloud;KHATOUI, NIHAL
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Strategies for repositioning and forming eutectic mixtures by binary combination of Active Principle/Coformer or Active Principle/Active Principle are widely used to combat multi-resistant bacteria and increase solubility, bioavailability and consequently therapeutic effect. The choice of coformer is based on its chemical structure and the presence of proton-donating and proton-accepting functional groups capable of establishing non-covalent intermolecular interactions, such as hydrogen bonding, Van Der Waals forces and pi-pi interactions. The active ingredient chosen for repositioning is…mehr

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Produktbeschreibung
Strategies for repositioning and forming eutectic mixtures by binary combination of Active Principle/Coformer or Active Principle/Active Principle are widely used to combat multi-resistant bacteria and increase solubility, bioavailability and consequently therapeutic effect. The choice of coformer is based on its chemical structure and the presence of proton-donating and proton-accepting functional groups capable of establishing non-covalent intermolecular interactions, such as hydrogen bonding, Van Der Waals forces and pi-pi interactions. The active ingredient chosen for repositioning is Celecoxib. The coformers are salicylic acid (A.SAL), maleic acid (A.MAL), nicotinamide (NIC), succinic acid (A.SUC) and cinnamic acid (A.CIN).
Autorenporträt
ALLAL Farida, dottore di ricerca in chimica da aprile 2017, docente presso l'Università Amar Telidji di Laghouat. Lavora alla determinazione e alla previsione delle proprietà termodinamiche degli eccessi di sistemi binari e ternari.