Antifungal Resistance: Mechanisms, Detection and Perspectives - Belgacem, Sameh;Belhaj, Oussama;Babba, Hamouda
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The use of antifungal agents is essential in the treatment of mycoses, especially in immunocompromised patients. However, the rise in resistance is compromising treatment efficacy, due to genetic mutations, activation of efflux pumps, and biofilm formation. Faced with this challenge, it is crucial to strengthen epidemiological surveillance and improve detection methods. Prospects for control include optimizing combination therapies, developing new molecules targeting fungal virulence mechanisms, and promoting more rational use of antifungal agents to prevent the emergence of new resistances.

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Produktbeschreibung
The use of antifungal agents is essential in the treatment of mycoses, especially in immunocompromised patients. However, the rise in resistance is compromising treatment efficacy, due to genetic mutations, activation of efflux pumps, and biofilm formation. Faced with this challenge, it is crucial to strengthen epidemiological surveillance and improve detection methods. Prospects for control include optimizing combination therapies, developing new molecules targeting fungal virulence mechanisms, and promoting more rational use of antifungal agents to prevent the emergence of new resistances.
Autorenporträt
Dr. Sameh BelgacemUniversity Hospital Assistant in Parasitology and Mycology. Faculty of Pharmacy, Monastir. Microbiology Laboratory, CHU Fattouma Bourguiba. National Master's degree in medical biology and health technology. Member of the Parasitology-Mycology Medical and Molecular research laboratory.