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According to statistical data, with the development of oil, chemical, gas industries cases of poisoning caused by toxic substances employed in these branches have become more frequent recently. A special place among them is occupied by carbon monoxide, poisoning with which has been growing steadily. The application of information technology in this field of medicine is explained by the complexity, uncertainty and multi-parameter nature of the problem. The fact that the majority of symptoms of carbon monoxide poisoning are found in other poisonings also contradicts the differential diagnosis. At the same time, considering such consequences of poisoning with carbon monoxide as myocardial infarction, gait and motor disturbance, peripheral neuropathy, dementia, Parkinsonism u.a. it is expedient to perform monitoring of a patient after staying in a stationary treatment which determines optimum time of its performance, kind and the number of analyses required for developing an intelligent system. This book proposes an elaboration of an intelligent information system for differential diagnosis and monitoring in cases of poisonings with carbon monoxide.