The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders: from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the…mehr
The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders: from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
List of contributors Part I. Introduction to Genetic Mouse Models of Neurobehavioral Disorders: 1. Introduction Frans Sluyter and Wim E. Crusio 2. Developing mouse models of neurobehavioral disorders: when is a model a good model? F. Josef van der Staay, Saskia Arndt and Rebecca E. Nordquist Part II. Perception Disorders: 3. Pain disorders Odd-Geir Berge 4. Disorders of the visual system Stewart Thompson and Alisdair R. Philp Part III. Autonomous and Motor Disorders: 5. Obesity and anorexia Gertjan van Dijk and Martien J. H. Kas 6. Sleep disorders Glenda Lassi and Valter Tucci 7. Cerebellar disorders Robert Lalonde and Catherine Strazielle 8. Motor disorders David Gordon and Kevin Talbot 9. Epilepsy Ortrud K. Steinlein Part IV. Social Dysfunction and Mental Retardation: 10. Pathological aggression Frans Sluyter, Aki Takahashi and Stephen C. Maxson 11. Disorders of sex Ashlyn Swift-Gallant and Douglas Ashley Monks 12. Autism Valerie J. Bolivar 13. Rett syndrome Laura Ricceri, Bianca De Filippis and Giovanni Laviola 14. Fragile X syndrome Susanna Pietropaolo and E. Subashi 15. Attention-deficit hyperactivity disorder Tatyana D. Sotnikova and Raul R. Gainetdinov 16. Obsessive-compulsive disorder and Gilles de la Tourette's syndrome Nancy S. Woehrle and Stephanie C. Dulawa 17. Schizophrenia Sofya Abazyan and Mikhail V. Pletnikov 18. Down syndrome Mara Dierssen 19. Prader-Willi and Angelmann syndromes Emily Y. Smith and James L. Resnick 20. Williams syndrome Lucy R. Osborne and Zhengping Jia Part V. Anxiety and Mood Disorders: 21. Anxiety disorders Guy Griebel and Sandra Beeské 22. Depression Christopher R. Pryce and Federica Klaus 23. Bipolar disorder Nirit Kara and Haim Einat Part VI. Substance Dependence and Abuse: 24. Alcohol use disorders John C. Crabbe 25. Drug abuse: nicotine Rebecca C. Steiner and Marina R. Picciotto 26. Cannabis abuse and dependence Tim Karl and Jonathon C. Arnold 27. Drug abuse: amphetamines Tamara J. Phillips, Emily C. Eastwood and John H. Harkness 28. Cocaine-related disorders F. Scott Hall and Ichiro Sora 29. Opioids-related disorders Angelo Contarino Part VII. Neurodegenerative Disorders: 30. Alzheimer's disease Christopher Janus and David Borchelt 31. Parkinson's disease Iddo Magen and Marie-Françoise Chesselet 32. Huntington's disease Yoon H. Cho and Susanna Pietropaolo Index.
List of contributors Part I. Introduction to Genetic Mouse Models of Neurobehavioral Disorders: 1. Introduction Frans Sluyter and Wim E. Crusio 2. Developing mouse models of neurobehavioral disorders: when is a model a good model? F. Josef van der Staay, Saskia Arndt and Rebecca E. Nordquist Part II. Perception Disorders: 3. Pain disorders Odd-Geir Berge 4. Disorders of the visual system Stewart Thompson and Alisdair R. Philp Part III. Autonomous and Motor Disorders: 5. Obesity and anorexia Gertjan van Dijk and Martien J. H. Kas 6. Sleep disorders Glenda Lassi and Valter Tucci 7. Cerebellar disorders Robert Lalonde and Catherine Strazielle 8. Motor disorders David Gordon and Kevin Talbot 9. Epilepsy Ortrud K. Steinlein Part IV. Social Dysfunction and Mental Retardation: 10. Pathological aggression Frans Sluyter, Aki Takahashi and Stephen C. Maxson 11. Disorders of sex Ashlyn Swift-Gallant and Douglas Ashley Monks 12. Autism Valerie J. Bolivar 13. Rett syndrome Laura Ricceri, Bianca De Filippis and Giovanni Laviola 14. Fragile X syndrome Susanna Pietropaolo and E. Subashi 15. Attention-deficit hyperactivity disorder Tatyana D. Sotnikova and Raul R. Gainetdinov 16. Obsessive-compulsive disorder and Gilles de la Tourette's syndrome Nancy S. Woehrle and Stephanie C. Dulawa 17. Schizophrenia Sofya Abazyan and Mikhail V. Pletnikov 18. Down syndrome Mara Dierssen 19. Prader-Willi and Angelmann syndromes Emily Y. Smith and James L. Resnick 20. Williams syndrome Lucy R. Osborne and Zhengping Jia Part V. Anxiety and Mood Disorders: 21. Anxiety disorders Guy Griebel and Sandra Beeské 22. Depression Christopher R. Pryce and Federica Klaus 23. Bipolar disorder Nirit Kara and Haim Einat Part VI. Substance Dependence and Abuse: 24. Alcohol use disorders John C. Crabbe 25. Drug abuse: nicotine Rebecca C. Steiner and Marina R. Picciotto 26. Cannabis abuse and dependence Tim Karl and Jonathon C. Arnold 27. Drug abuse: amphetamines Tamara J. Phillips, Emily C. Eastwood and John H. Harkness 28. Cocaine-related disorders F. Scott Hall and Ichiro Sora 29. Opioids-related disorders Angelo Contarino Part VII. Neurodegenerative Disorders: 30. Alzheimer's disease Christopher Janus and David Borchelt 31. Parkinson's disease Iddo Magen and Marie-Françoise Chesselet 32. Huntington's disease Yoon H. Cho and Susanna Pietropaolo Index.
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