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Prowedena razrabotka i obosnowanie nowoj metodologii poiska sowremennyh biologicheski aktiwnyh soedinenij i potencial'nyh lekarstwennyh sredstw putem analiza literaturnyh swedenij ob ih aktiwnosti i sinteza analogow priznannyh, patentowannyh lekarstwennyh sredstw, naprimer, dzhenerikow, ih posleduüschej naprawlennoj funkcionalizacii dlq wyqwleniq wliqniq himicheskoj modifikacii farmakofornogo fragmenta na rost ili ubyl' opredelennoj, harakternoj dlq ätih lekarstwennyh sredstw biologicheskoj aktiwnosti, obschej toxichnosti, rastworimosti w biologicheskih zhidkostqh, skorosti wywedeniq produktow ego metabolizma i t.d.