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Beta-thalassemia, an inherited genetic disorder affecting hemoglobin production, has long been managed by conventional treatments such as regular blood transfusions and iron chelation. In this new era, innovative approaches are emerging to transform the management of beta-thalassemia. Gene therapy, which targets the genetic abnormalities that cause the disease, promises more sustainable and potentially curative solutions.This book explores the journey of beta-thalassemia, from conventional treatment to promising innovations. It examines current challenges, recent advances and future prospects, offering a comprehensive overview for healthcare professionals, patients and their families. By highlighting the progress made and the hopes raised by new technologies, it underlines the importance of continuous innovation to improve the lives of people with this complex disease.