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Bile Duct Cancer is a common type of malignant tumor of the biliary tract, starting from Cholangiocarcinoma (CAA) of the hilar region, characterized by an insidious onset, and is a prevalent malignant tumor in the biliary tract. Its diagnosis and treatment encompass multiple aspects, including epidemiology, clinical evaluation, imaging studies, pathological classification, staging, resectability assessment, perioperative management, surgical decision-making, systemic therapy, and follow-up monitoring. The contents of the book include the following chapters: 1. Bile Duct Cancer: From Bench to Bedside - Latest Developments offers a discussion on the latest treatment strategies and research developments for this challenging biliary tract cancer. 2. Cholangiocarcinoma - A Comprehensive Review of Diagnostic Challenges and Novel Therapeutic Approaches offers an exploration of bile duct cancer research, blending scientific rigor with accessibility. 3. Diagnosis, Imaging, and Prognostic Evaluation in Cholangiocarcinoma provides a comprehensive exploration of CCA. 4. Multiomics Approaches for the Identification of Biomarkers and Therapeutic Targets in Cholangiocarcinoma dives into the integration of genomics, transcriptomics, epigenomics, proteomics, and metabolomics, unveiling a comprehensive molecular landscape of CCA. 5. Optimising Therapeutic Options for Bile Duct Cancer in the Era of Molecular Profiling, Immunotherapy and Pharmacogenomics engages readers by exploring the latest strategies to enhance cholangiocarcinoma treatment.