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This book explores the critical dimensions of integrating bioelectronic systems for health monitoring, with a focus on their architectural aspects. The discussion delves into the complex interaction between various components, such as sensors, processors and communication modules, within these systems. Emphasis is placed on achieving seamless integration to increase the efficiency and reliability of health monitoring devices. The chapter also addresses the main challenges associated with architectural design, offering insights into optimizing energy consumption, ensuring data accuracy and promoting user-friendly interfaces. By providing a comprehensive overview of integration strategies and architectural considerations, the chapter contributes to advancing the development of bioelectronic systems that play a key role in modern health monitoring applications.