Biophysics of Tissue Self-Organization in Morphogenesis: The Role of Dynamics Along the Biointerface delves into the interactions between tissue and the extracellular matrix. It explores the fundamentals of cell self-rearrangement and the interrelation between biological mechanisms and physical principles responsible for tissue self-organization. The book examines modeling approaches to tissue self-organization and the application of engineering principles to solve medical problems. It also discusses tools, applications, and medical implications, particularly in embryo development, wound…mehr
Biophysics of Tissue Self-Organization in Morphogenesis: The Role of Dynamics Along the Biointerface delves into the interactions between tissue and the extracellular matrix. It explores the fundamentals of cell self-rearrangement and the interrelation between biological mechanisms and physical principles responsible for tissue self-organization. The book examines modeling approaches to tissue self-organization and the application of engineering principles to solve medical problems. It also discusses tools, applications, and medical implications, particularly in embryo development, wound healing, and cancerous diseases, concluding with future developments. Covering subcellular to supracellular levels, this book is an interdisciplinary guide for researchers in cell biology, biophysics, developmental biology, and more.
Section 1: Tissues self-organisation in morphogenesis 1. Cell adhesion: Common mechanisms and physical principles 2. Analysis of the effect of cell movement on gene expression dynamics in development 3. Force transmission across scales: Examples and measuring methods 4. The impact of air pollution on the tissue self-organisation within co[1]cultured lung systems Section 2: Physics of tissue self-organisation from subcellular to supracellular levels 5. How physical cues guide cell collectives, from local adhesion to global force transmission 6. Cellular death and division events at tissue interfaces: A chicken-or[1]the-egg situation 7. Active Nematics: Exploring the Interplay between structure and dynamics in cell cultures 8. The dynamics along the epithelial-cancer bio-interface within co[1]cultured cell spheroids: Physical aspects 9. Dynamical interplay at the interfaces of cancer cells, immune cells and stromal cells in the extracellular space of artificial model systems and tissues 10. Techniques development to quantify cell-scale dynamic mechanical interactions in extracellular matrices of tissues Section 3: Modeling of the tissue self[1]organization 11. Mathematical modelling approaches to collective cell movement: Leader vs. follower cells Section 4: Engineering of human tissues 12. Engineering of human tissues 13. Conclusion and outlook
Section 1: Tissues self-organisation in morphogenesis 1. Cell adhesion: Common mechanisms and physical principles 2. Analysis of the effect of cell movement on gene expression dynamics in development 3. Force transmission across scales: Examples and measuring methods 4. The impact of air pollution on the tissue self-organisation within co[1]cultured lung systems Section 2: Physics of tissue self-organisation from subcellular to supracellular levels 5. How physical cues guide cell collectives, from local adhesion to global force transmission 6. Cellular death and division events at tissue interfaces: A chicken-or[1]the-egg situation 7. Active Nematics: Exploring the Interplay between structure and dynamics in cell cultures 8. The dynamics along the epithelial-cancer bio-interface within co[1]cultured cell spheroids: Physical aspects 9. Dynamical interplay at the interfaces of cancer cells, immune cells and stromal cells in the extracellular space of artificial model systems and tissues 10. Techniques development to quantify cell-scale dynamic mechanical interactions in extracellular matrices of tissues Section 3: Modeling of the tissue self[1]organization 11. Mathematical modelling approaches to collective cell movement: Leader vs. follower cells Section 4: Engineering of human tissues 12. Engineering of human tissues 13. Conclusion and outlook
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