For Senior-level and graduate courses in Biochemical Engineering, and for programs in Agricultural and Biological Engineering or Bioengineering. This concise yet comprehensive text introduces the essential concepts of bioprocessing internal structure and functions of different types of microorganisms, major metabolic pathways, enzymes, microbial genetics, kinetics and stoichiometry of growth and product information to traditional chemical engineers and those in related disciplines. It explores the engineering principles necessary for bioprocess synthesis and design, and illustrates the…mehr
For Senior-level and graduate courses in Biochemical Engineering, and for programs in Agricultural and Biological Engineering or Bioengineering.
This concise yet comprehensive text introduces the essential concepts of bioprocessing internal structure and functions of different types of microorganisms, major metabolic pathways, enzymes, microbial genetics, kinetics and stoichiometry of growth and product information to traditional chemical engineers and those in related disciplines. It explores the engineering principles necessary for bioprocess synthesis and design, and illustrates the application of these principles to modern biotechnology for production of pharmaceuticals and biologics, solution of environmental problems, production of commodities, and medical applications.
Preface to the Second Edition. Preface to the First Edition. I. INTRODUCTION. 1. What is a Bioprocess Engineer?
Introductory Remarks. Biotechnology and Bioprocess Engineering. Biologists and Engineers Differ in Their Approach to Research. The Story of Penicillin: How Biologists and Engineers Work Together. Bioprocesses: Regulatory Constraints. Suggestions for Further Reading. Problems.
II. THE BASICS OF BIOLOGY: AN ENGINEER'S PERSPECTIVE. 2. An Overview of Biological Basics.
Are All Cells the Same? Cell Construction. Cell Nutrients. Summary. Suggestions for Further Reading. Problems.
3. Enzymes.
Introduction. How Enzymes Work. Enzyme Kinetics. Immobilized Enzyme Systems. Large-scale Production of Enzymes. Medical and Industrial Utilization of Enzymes. Summary. Suggestions for Further Reading. Problems.
4. How Cells Work.
Introduction. The Central Dogma. DNA Replication: Preserving and Propagating the Cellular Message. Transcription: Sending the Message. Translation: Message to Product. Metabolic Regulation. How the Cell Senses Its Extracellular Environment. Summary. Appendix: Examples of Regulation of Complex Pathways. Suggestions for Further Reading. Problems.
5. Major Metabolic Pathways.
Introduction. Bioenergetics. Glucose Metabolism: Glycolysis and the TCA Cycle. Respiration. Control Sites in Aerobic Glucose Metabolism. Metabolism of Nitrogenous Compounds. Nitrogen Fixation. Metabolism of Hydrocarbons. Overview of Biosynthesis. Overview of Anaerobic Metabolism. Overview of Autotrophic Metabolism. Summary. Suggestions for Further Reading. Problems.
6. How Cells Grow.
Introduction. Batch Growth. Quantifying Growth Kinetics. How Cells Grow in Continuous Culture. Summary. Suggestions for Further Reading. Problems.
7. Stoichiometry of Microbial Growth and Product Formation.
Introduction. Some Other Definitions. Stoichiometric Calculations. Theoretical Predictions of Yield Coefficients. Summary. Suggestions for Further Reading. Problems.
8. How Cellular Information is Altered.
Introduction. Evolving Desirable Biochemical Activities through Mutation and Selection. Natural Mechanisms for Gene Transfer and Rearrangement. Genetically Engineering Cells. Genomics. Summary. Suggestions for Further Reading. Problems.
III. ENGINEERING PRINCIPLES FOR BIOPROCESSES. 9. Operating Considerations for Bioreactors for Suspension and Immobilized Cultures.
Introduction. Choosing the Cultivation Method. Modifying Batch and Continuous Reactors. Immobolized Cell Systems. Solid-state Fermentations. Summary. Suggestions for Further Reading. Problems.
10. Selection, Scale-Up, Operation, and Control of Bioreactors.
Introduction. Scale-up and Its Difficulties. Bioreactor Instrumentation and Control. Sterilization of Process Fluids. Summary. Suggestions for Further Reading. Problems.
11. Recovery and Purification of Products.
Strategies to Recover and Purify Products. Separation of Insoluble Products. Cell Disruption. Separation of Soluble Products. Finishing Steps for Purification. Integration of Reaction and Separation. Summary. Suggestions for Further Reading. Problems.
IV. APPLICATIONS TO NONCONVENTIONAL BIOLOGICAL SYSTEMS. 12. Bioprocess Considerations in Using Animal Cell Cultures.
Structure and Biochemistry of Animal Cells. Methods Used for the Cultivation of Animal Cells. Bioreactor Considerations for Animal Cell Culture. Products of Animal Cell Cultures. Summary. Suggestions for Further Reading. Problems.
Preface to the Second Edition. Preface to the First Edition. I. INTRODUCTION. 1. What is a Bioprocess Engineer?
Introductory Remarks. Biotechnology and Bioprocess Engineering. Biologists and Engineers Differ in Their Approach to Research. The Story of Penicillin: How Biologists and Engineers Work Together. Bioprocesses: Regulatory Constraints. Suggestions for Further Reading. Problems.
II. THE BASICS OF BIOLOGY: AN ENGINEER'S PERSPECTIVE. 2. An Overview of Biological Basics.
Are All Cells the Same? Cell Construction. Cell Nutrients. Summary. Suggestions for Further Reading. Problems.
3. Enzymes.
Introduction. How Enzymes Work. Enzyme Kinetics. Immobilized Enzyme Systems. Large-scale Production of Enzymes. Medical and Industrial Utilization of Enzymes. Summary. Suggestions for Further Reading. Problems.
4. How Cells Work.
Introduction. The Central Dogma. DNA Replication: Preserving and Propagating the Cellular Message. Transcription: Sending the Message. Translation: Message to Product. Metabolic Regulation. How the Cell Senses Its Extracellular Environment. Summary. Appendix: Examples of Regulation of Complex Pathways. Suggestions for Further Reading. Problems.
5. Major Metabolic Pathways.
Introduction. Bioenergetics. Glucose Metabolism: Glycolysis and the TCA Cycle. Respiration. Control Sites in Aerobic Glucose Metabolism. Metabolism of Nitrogenous Compounds. Nitrogen Fixation. Metabolism of Hydrocarbons. Overview of Biosynthesis. Overview of Anaerobic Metabolism. Overview of Autotrophic Metabolism. Summary. Suggestions for Further Reading. Problems.
6. How Cells Grow.
Introduction. Batch Growth. Quantifying Growth Kinetics. How Cells Grow in Continuous Culture. Summary. Suggestions for Further Reading. Problems.
7. Stoichiometry of Microbial Growth and Product Formation.
Introduction. Some Other Definitions. Stoichiometric Calculations. Theoretical Predictions of Yield Coefficients. Summary. Suggestions for Further Reading. Problems.
8. How Cellular Information is Altered.
Introduction. Evolving Desirable Biochemical Activities through Mutation and Selection. Natural Mechanisms for Gene Transfer and Rearrangement. Genetically Engineering Cells. Genomics. Summary. Suggestions for Further Reading. Problems.
III. ENGINEERING PRINCIPLES FOR BIOPROCESSES. 9. Operating Considerations for Bioreactors for Suspension and Immobilized Cultures.
Introduction. Choosing the Cultivation Method. Modifying Batch and Continuous Reactors. Immobolized Cell Systems. Solid-state Fermentations. Summary. Suggestions for Further Reading. Problems.
10. Selection, Scale-Up, Operation, and Control of Bioreactors.
Introduction. Scale-up and Its Difficulties. Bioreactor Instrumentation and Control. Sterilization of Process Fluids. Summary. Suggestions for Further Reading. Problems.
11. Recovery and Purification of Products.
Strategies to Recover and Purify Products. Separation of Insoluble Products. Cell Disruption. Separation of Soluble Products. Finishing Steps for Purification. Integration of Reaction and Separation. Summary. Suggestions for Further Reading. Problems.
IV. APPLICATIONS TO NONCONVENTIONAL BIOLOGICAL SYSTEMS. 12. Bioprocess Considerations in Using Animal Cell Cultures.
Structure and Biochemistry of Animal Cells. Methods Used for the Cultivation of Animal Cells. Bioreactor Considerations for Animal Cell Culture. Products of Animal Cell Cultures. Summary. Suggestions for Further Reading. Problems.
13. B
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