Biotechnology of Microbial Enzymes

Production, Biocatalysis, and Industrial Applications
Herausgegeben:Brahmachari, Goutam

• Broschiertes Buch

Produktbeschreibung

Biotechnology of Microbial Enzymes: Production, Biocatalysis, and Industrial Applications, Second Edition provides a complete survey of the latest innovations on microbial enzymes, highlighting biotechnological advances in their production and purification along with information on successful applications as biocatalysts in several chemical and industrial processes under mild and green conditions.

The application of recombinant DNA technology within industrial fermentation and the production of enzymes over the last three decades have produced a host of useful chemical and biochemical substances. The power of these technologies results in novel transformations, better enzymes, a wide variety of applications, and the unprecedented development of biocatalysts through the ongoing integration of molecular biology methodology, all of which is covered insightfully and in-depth within the book.

This fully revised, second edition is updated to address the latest research developments and applications in the field, from microbial enzymes recently applied in drug discovery to penicillin biosynthetic enzymes and penicillin acylase, xylose reductase, and microbial enzymes used in antitubercular drug design. Across the chapters, the use of microbial enzymes in sustainable development and production processes is fully considered, with recent successes and ongoing challenges highlighted.

Produktdetails

• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: C2021-0-03359-9
• 2. Aufl.
• Seitenzahl: 838
• Erscheinungstermin: 23. Januar 2023
• Englisch
• Abmessung: 154mm x 232mm x 50mm
• Gewicht: 1310g
• ISBN-13: 9780443190599
• ISBN-10: 0443190593
• Artikelnr.: 66165605

Autorenporträt

Goutam Brahmachari is a Professor of Chemistry at Visva-Bharati University, India, with over 25 years of teaching and research experience. He specializes in synthetic organic chemistry, green chemistry, natural products chemistry, and medicinal chemistry of natural and synthetic molecules. Prof. Brahmachari has authored or edited 27 books with leading international publishers and serves as co-editor-in-chief of Current Green Chemistry, as well as being the founding series editor of Elsevier's Natural Product Drug Discovery series. An elected Fellow of the Royal Society of Chemistry, he has received prestigious awards such as the CRSI Bronze Medal (2021) and the INSA Teachers Award (2019).

Inhaltsangabe

1. Biotechnology of microbial enzymes: production, biocatalysis, and industrial applications-an overview
Goutam Brahmachari

1.1 Introduction
1.2 An overview of the book
1.2.1 Chapter 2
1.2.2 Chapter 3
1.2.3 Chapter 4
1.2.4 Chapter 5
1.2.5 Chapter 6
1.2.6 Chapter 7
1.2.7 Chapter 8
1.2.8 Chapter 9
1.2.9 Chapter 10
1.2.10 Chapter 11
1.2.11 Chapter 12
1.2.12 Chapter 13
1.2.13 Chapter 14
1.2.14 Chapter 15
1.2.15 Chapter 16
1.2.16 Chapter 17
1.2.17 Chapter 18
1.2.18 Chapter 19
1.2.19 Chapter 20
1.2.20 Chapter 21
1.2.21 Chapter 22
1.2.22 Chapter 23
1.2.23 Chapter 24
1.2.24 Chapter 25
1.2.25 Chapter 26
1.3 Concluding remarks

2. Useful microbial enzymes-an introduction
Beatriz Ruiz-Villafa´n, Romina Rodri´guez-Sanoja and Sergio Sa´nchez

2.1 The enzymes: a class of useful biomolecules
2.2 Microbial enzymes for industry
2.3 Improvement of enzymes
2.4 Discovery of new enzymes
2.5 Concluding remarks
Acknowledgments
Abbreviations
References

3. Production, purification, and application of microbial enzymes
Anil Kumar Patel, Cheng-Di Dong, Chiu-Wen Chen, Ashok Pandey and Reeta Rani Singhania

3.1 Introduction
3.2 Production of microbial enzymes
3.2.1 Enzyme production in industries
3.2.2 Industrial enzyme production technology
3.3 Strain improvements
3.3.1 Mutation
3.3.2 Recombinant DNA technology
3.3.3 Clustered regularly interspaced short palindromic repeats-Cas9 technology
3.3.4 Protein engineering
3.4 Downstream processing/enzyme purification
3.5 Product formulations
3.6 Global enzyme market scenarios
3.7 Industrial applications of enzymes
3.7.1 Food industry
3.7.2 Textile industry
3.7.3 Detergent industry
3.7.4 Pulp and paper industry
3.7.5 Animal feed industry
3.7.6 Leather industry
3.7.7 Biofuel from biomass
3.7.8 Enzyme applications in the chemistry and pharma sectors
3.8 Concluding remarks
Abbreviations
References

4. Solid-state fermentation for the production of microbial cellulases
Sudhanshu S. Behera, Ankush Kerketta and Ramesh C. Ray

4.1 Introduction
4.2 Solid-state fermentation
4.2.1 Comparative aspects of solid-state and submerged fermentations
4.2.2 Cellulase-producing microorganisms in solid-state fermentation
4.2.3 Extraction of microbial cellulase in solid-state fermentation
4.2.4 Measurement of cellulase activity in solid-state fermentation
4.3 Lignocellulosic residues/wastes as solid substrates in solid-state fermentation
4.4 Pretreatment of agricultural residues
4.4.1 Physical pretreatments
4.4.2 Physiochemical pretreatment
4.4.3 Chemical pretreatments
4.4.4 Biological pretreatment
4.5 Environmental factors affecting microbial cellulase production in solid-state fermentation
4.5.1 Water activity/moisture content
4.5.2 Temperature
4.5.3 Mass transfer processes: aeration and nutrient diffusion
4.5.4 Substrate particle size
4.5.5 Other factors
4.6 Strategies to improve production of microbial cellulase
4.6.1 Metabolic engineering and strain improvement
4.6.2 Recombinant strategy (heterologous cellulase expression)
4.6.3 Mixed-culture (coculture) systems
4.7 Fermenter (bioreactor) design for cellulase production in solid-state fermentation
4.7.1 Tray bioreactor
4.7.2 Packed bed reactor
4.7.3 Rotary drum bioreactor
4.7.4 Fluidized bed reactor
4.8 Biomass conversions and application of microbial cellulase
4.8.1 Textile industry
4.8.2 Laundry and detergent
4.8.3 Paper and pulp industry
4.8.4 Bioethanol and biofuel production
4.8.5 Food indust