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This was a study for patients with Periodontitis. This clinical study consisted of 20 patients between the age group of 30-60 years. Study showed the presence of elevated levels of C-Reactive protein in gingival crevicular fluid of patients with periodontitis. Non-surgical periodontal treatment was effective in reducing the levels of C-Reactive protein in gingival crevicular fluid. This study data support the hypothesis that levels of gingival crevicular fluid biomarkers specific for three aspects of periodontitis inflammation, collagen degradation and bone turnover correlate with the clinical features of periodontal disease and suggest that elevated gingival crevicular fluid levels of C-Reactive protein are candidate biomarkers of periodontal disease. Hence gingival crevicular fluid CRP determination should always be considered as inflammatory marker before treatment of Periodontitis.