Cerebrovascular Disease

22nd Princeton Conference
Herausgeber: Chan, Pak H.

• Broschiertes Buch

Produktbeschreibung

Prevention, diagnosis and treatment are the watchwords in stroke research, for basic neuroscientists and clinicians alike. This 2002 book, from the 22nd Princeton Conference on Cerebrovascular Disease, contains contributions from outstanding investigators on numerous topics in stroke research. The contents cover the status and future directions of stroke pathophysiology, diagnosis and treatment, with special emphasis on the molecular and cellular mechanisms of ischaemic cell death and repair, and clinical issues including imaging, risk factors and therapeutic strategies in stroke. Available in both print and online formats, this survey of the basic and clinical science of stroke is an essential resource for all involved in advancing knowledge of cerebrovascular disease.

Produktdetails

• Verlag: Cambridge University Press
• Seitenzahl: 488
• Erscheinungstermin: 6. Dezember 2010
• Englisch
• Abmessung: 244mm x 170mm x 26mm
• Gewicht: 834g
• ISBN-13: 9780521187534
• ISBN-10: 0521187532
• Artikelnr.: 33152829

Inhaltsangabe

Part I: 1. Zinc toxicity in the ischemic brain; 1. 2. Central nervous
system ischemia: diversity among the caspases; Part II: 3. Peroxynirite and
injury to the vasculature and central nervous system in stroke and
neurodegeneration; 4. Interaction between inducible nitric oxide and
cyclooxygenase-2 in ischemic brain injury; 5. Mechanisms of ischemic
tolerance; 6. Clinically-tolerated NMDA receptor antagonists and newly
cloned NMDA receptor subunits that mimic them; Part III: 7. Cell death
programs in neutral development and disease; 8. Apoptotic gene expression
in brain Ischemia and ischemic tolerance; 9. Cellular mechanisms of white
matter ischemia: what can we learn from culture models?; Part IV: 10.
Astrocytes in ischemic stroke; 11. Aquaporin-4 water channels and brain
edema; 12. Neuroprotection with tetracyclines in brain ischemia models; 13.
Spreading depression: a teleologic means for self-protection from brain
ischemia; Part V: 14. The role of matrix metalloproteinases and urokinase
in blood-brain barrier damage with thrombolysis; 15. Does brain nitric
oxide generation influence tissue oxygenation after severe human
subarachnoid hemorrhage?; 16. Tissue plasminogen activator and hemorrhagic
brain injury; 17. Dynamics of infarct evolution after permanent and
transient focal brain ischemia in mice; Part VI: 18. Inflammation and
stroke: benefits or harm?; 19. TNF-a and ceramide are involved in the
mediation of neuronal tolerance to brain ischemia; 20. Sites and mechanisms
of IL-1 action in ischemic and excitotoxic brain damage; 21. Protease
generation, inflammation and cerebral microvascular activation; Part VII:
22. Adenoviral vectors for gene therapy in stroke; 23. Gene transfer of
glial cell line-derived neurotrophic factor prevents ischemic brain injury;
24. Vasomotor effects of nitric oxide, superoxide dismutases and calcitonin
gene-related peptide; Part VIII: 25. Transplantation of neural stem cells:
cellular and gene therapy in pediatric hypoxic-ischemic brain injury; 26.
Neural plasticity after cerebral ischemia; 27. Environmental effects on
recovery after stroke; Part IX: 28. Magnetic resonance imaging in stroke
trials; 29. Disappearing deficits and disappearing lesions:
diffusion/perfusion MRI in TIA and intra-arterial thrombolysis; 30.
Diffusion and perfusion magnetic resonance imaging in the evaluation of
acute ischemic stroke; 31. Early recanalization in acute ischemic stroke
saves tissue at risk defined by stroke magnetic resonance imaging; Part X:
32. Vascular factors in Alzheimer's disease; 33. Beyond neuroprotection:
the protection of axons and oligodendrocytes in cerebral ischemia; 34.
Combining neuroprotection with thrombolysis: how to translate laboratory
success to our clinical trials; 35. Prospects for improved neuroprotection
trials in stroke; 36. Basic research and stroke therapeutics: what have we
learned?