Chalcones

From Drug Discovery to Pharmaceutical Applications
Herausgeber: Carradori, Simone; D'Agostino, Ilaria; Moi, Davide

• Broschiertes Buch

Produktbeschreibung

Chalcones: From Drug Discovery to Pharmaceutical Applications serves as a comprehensive reference on chalcones, detailing their natural occurrence, synthetic methods, and therapeutic applications. The book provides both novice and experienced researchers with the foundational knowledge necessary to advance their work in this area. Sections cover the natural sources of chalcones, various extraction methods, structural characterization techniques, synthesis, and their role in organic chemistry and metal complexes, while also addressing pharmacokinetic properties, toxicity, and the medicinal uses of chalcones, including their effectiveness against viruses, bacteria, cancer, and neurodegenerative diseases. Final sections explore chalcone-containing products, drug formulation strategies, and clinical trials involving chalcone-based drug candidates. This reference is an essential resource for pharmaceutical researchers, providing critical insights into the applications and potential of chalcones in drug development and therapeutic interventions.

Produktdetails

• Verlag: Elsevier Science
• Seitenzahl: 500
• Erscheinungstermin: 1. April 2026
• Englisch
• Gewicht: 450g
• ISBN-13: 9780443438127
• ISBN-10: 0443438129
• Artikelnr.: 75039514

Inhaltsangabe

Part I - Foundations of Chalcones research
1. Natural sources of Chalcones
2. Extraction methods from traditional to green approaches
3. Structural and spectroscopic characterization of Chalcones
4. Synthesis, structural modifications and scale-up methods
5. Medicinal Chemistry Strategies in the Chalcone scaffold
6. Chalcones as versatile intermediates in organic chemistry
7. Chalcones in metal complexes
Part II - Pharmacology of Chalcones
8. PK properties and bioavailability of Chalcones
9. Chalcone Toxicity
10. Natural Chalcones in Traditional Medicine
11. Chalcones as Antiviral Agents
12. Chalcones as Antibacterial and Antitubercular Agents
13. Anticancer Potential of Chalcones
14. Chalcones as Neuroprotective and Anti-Alzheimer’s Disease Agents
15. Chalcones as Antiprotozoal, Antiparasitic and Insecticidal Agents
16. Chalcones as Antifungal Agents
17. Chalcones as Anti-inflammatory, Anti-ulcer and Antioxidant Agents
18. Chalcones as Anti-hyperlipidemic, Anti-diabetic and Insulin Regulating
Agents
Part III - Prospects
19. Chalcone-containing Products (food supplements, nutraceuticals,
functional food)
20. Formulations and Drug Delivery of Chalcones
21. Chalcone-protein co-crystals in the PDB
22. Clinical Trials of Chalcone-based drug candidates