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This reprint provides an essential comprehensive overview of chronic pain research. New research developments, clinical updates and treatments' perspectives in chronic pain-in general and specific chronic pain conditions, with a particular focus on chronic noncancer pain, cancer pain, chronic tension-type headaches, chronic neck pain, shoulder pain, chronic back pain, fibromyalgia syndrome, and degenerative lumbar spinal stenosis-are described and discussed. Future trends on the topic are also covered.