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This book presents a guide for medical students and other interested audience. The first part of the book deals with Problem Based Learning (PBL). PBL of endocrine and neuroscience have been included. Every problem has a solution. Disease is caused by transgression of health laws. The second part of our book deals with Objective Structured Clinical Examination (OSCE). It provides the means to understand and assess patient's state in a structured manner. It may also be used to assess students' learning for an examination.