Computational Exploration of Novel Antifungal Drugs - Bouamrane, Soukaina;Maghat, Hamid;Bouachrine, Mohammed
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In recent decades, there has been a substantial increase fungal infection (IFI), posing a significant threat to human health. Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus are the predominant pathogens responsible for the majority of IFIs in clinical settings. Despite advances in antifungal therapy, IFIs remain a major cause of morbidity and mortality, especially in immunocompromised and HIV-infected patients. The primary therapeutic families for fungal infections include polyenes, fluoropyrimidines, azoles, allylamines, and echinocandins. However, these antifungal drugs…mehr

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Produktbeschreibung
In recent decades, there has been a substantial increase fungal infection (IFI), posing a significant threat to human health. Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus are the predominant pathogens responsible for the majority of IFIs in clinical settings. Despite advances in antifungal therapy, IFIs remain a major cause of morbidity and mortality, especially in immunocompromised and HIV-infected patients. The primary therapeutic families for fungal infections include polyenes, fluoropyrimidines, azoles, allylamines, and echinocandins. However, these antifungal drugs face challenges such as low water solubility, toxicity, narrow-spectrum activity, low bioavailability and, above all, the emergence of fungal drug resistance. To address the urgent medical need for improved antifungal agents, this book explores the application of Computer-Aided Drug Design (CADD) methods.
Autorenporträt
Soukaina Bouamrane é doutorada em Química pelo Laboratório de Química Molecular e Substâncias Naturais da Faculdade de Ciências da Universidade Moulay Ismail, Meknes, Marrocos. É especialista em conceção de medicamentos assistida por computador. Publicou numerosos artigos de investigação em várias revistas nacionais e internacionais de renome.