This latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field.
This latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field.
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Autorenporträt
Nigel Calcutt is Professor of Pathology at the University of California San Diego. Dr. Calcutt took his B.Sc. in Zoology at Nottingham University, England and then a Ph.D. in Physiology and Pharmacology while working in the laboratory of David Tomlinson. He performed post-doctoral research in the Departments of Pharmacology at St. Bartholomew's Hospital, London and Anesthesiology at the University of California San Diego, before being appointed to the faculty of the Department of Pathology at UCSD. Dr. Calcutt first began studying nerve damage caused by type 1 diabetes in 1983 as an undergraduate, with a largely unsuccessful but nevertheless enlightening attempt to generate diabetic chickens. Undeterred by his paltry progress with poultry, he has continued to investigate mechanisms of diabetic neuropathy and neuropathic pain throughout his scientific career, with a particular interest in developing therapies than can be translated to clinical use. Dr. Calcutt has published o
ver 100 research articles in this area and is funded by the National Institutes of Health for whom he serves on grant review and other administrative panels. Dr. Calcutt has also performed a number of roles for the Juvenile Diabetes Research Foundation, including membership of the Medical and Scientific Review Panel, Diabetic Complications Innovative Grants Review Panel (Chair) and Diabetic Complications Research Portfolio Advisory Committee (Chair).
Inhaltsangabe
Introduction: ?David Tomlinson (editor of first edition) "Back in my day.."
Fit the First: Clinical Context
Calcutt and Fernyhough: "An introduction to the history and controversies of clinical trials in diabetic neuropathy"
Pop-Busui: "Neuropathy in the DCCT/EDIC - what was done then and what we would do better now"
Bril: "The perfect?clinical trial"
Fit the Second: New Models of Diabetic Neuropathy
Calcutt and Fernyhough: "An Introduction to the history and controversies of animal models of diabetic neuropathy"
Gardiner and Freeman: "Can diabetic neuropathy be modeled in vitro?"
Yorek: "Alternatives to the streptozotocin-diabetic rodent"
Fit the Third: Mechanisms and Therapies
Fernyhough and Calcutt: "An introduction to the history and controversies of the pathogenesis of diabetic neuropathy"
Yagihashi: "Glucotoxic mechanisms and related therapeutic approaches"
Zochodne: "Sensory neurodegeneration in diabetes: beyond glucotoxicity "
