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Before Covid-19 global pandemic, vaccines were developed within few years, and there have been no vaccine available for preventing corona virus infections in humans. Research aiming at developing vaccines against Coronaviridae viruses family that infect humans and cause disease including severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) were conducted only in non-human animals. Therefore, there have been no approved vaccines against these earlier severe corona human infections. However, during, February 2021, eleven vaccines have been approved by at least one national regulatory authority for public use. The aim of this book is to provide an updated overview of covid-19 vaccines research.