Current management of chronic myelogenous leukemia - Siali, Nadjat;Fettal, Nadia
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Chronic myeloid leukemia constitutes a model in Onco-hematology, because it was the first chromosomal anomaly described in a malignant disease, but whose leukemogenesis has been particularly well studied, thus allowing major therapeutic advances. It is associated with a recurrent genetic anomaly: the Philadelphia chromosome, balanced reciprocal translocation t (9; 22), which results in a BCR-ABL fusion gene, then an abnormal protein with tyrosine kinase activity, responsible for leukemic transformation. It is also the first disease where molecular targeted therapy has been used successfully;…mehr

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Produktbeschreibung
Chronic myeloid leukemia constitutes a model in Onco-hematology, because it was the first chromosomal anomaly described in a malignant disease, but whose leukemogenesis has been particularly well studied, thus allowing major therapeutic advances. It is associated with a recurrent genetic anomaly: the Philadelphia chromosome, balanced reciprocal translocation t (9; 22), which results in a BCR-ABL fusion gene, then an abnormal protein with tyrosine kinase activity, responsible for leukemic transformation. It is also the first disease where molecular targeted therapy has been used successfully; including imatinib; these TKIs showed most mutations, except the dreaded T315I mutation. This led scientists to develop a third generation TKI; It's Ponatinib. These outpatient treatments allowed for better hematological, cytogenetic and molecular responses, associated with a better quality of life for patients. However, TKIs do not eradicate the disease. However, allogeneic hematopoietic stem cell transplantation remains the only curative treatment at present.
Autorenporträt
Siali NadjatAfter nine years of practice, I obtained the master's examination in 2011, thus beginning my university hospital career. In 2016, I enrolled in a thesis on chronic myelogenous leukemia, which I defended in 2022. I then passed the Docentat competition, becoming a lecturer A, a position I currently hold.