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Giving a brief account of Introduction to Cancer, Types of Cancer, Mechanism of Carcinogenesis, Molecular basis of cancer, Pathophysiology of Cancer and Tumor progression. Epidemiology of Cancer, Metabolic reprogramming of cells which includes Warburg Effect. And information related to Micro environmental acidosis which further includes Acidic Tumor Microenvironment & Therapeutic implications to target the Acidic Tumor Microenvironment followed by Discussion, Conclusion and Suggestion.