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In this monograph, the application of bentonites and palygorskites from different deposits in the production of drilling fluids can be quite different, due to the variability of composition and properties of the raw materials used. Special studies of their mineralogical and chemical compositions, as well as physical and chemical properties are required to determine their suitability for production of polyfunctional drilling muds. In Uzbekistan there are significant reserves of bentonite, palygorskite and hydrous clays not used as raw materials due to: insufficient study of their compositions and physical and chemical properties, as well as the lack of science-based technology and formulations for obtaining thermal and salt-resistant drilling fluids. In this aspect, the theoretical substantiation and experimental study of the use of some bentonites, palygorskites of Navbahorsk deposits and hydrous clays of Shorsuva deposits as a basis for obtaining thermal- and salt-resistant drilling fluids, as well as the development of the method of application of mechano-chemical dispersant in obtaining thermal- and salt-resistant drilling fluids from polymineral compositions is considered to be quite an urgent task.