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When Your Clinical Expertise Meets Complex Cases Treatment-resistant depression challenges even the most experienced clinicians. When patients don't respond to first- and second-line treatments, the path forward requires sophisticated clinical reasoning, familiarity with advanced interventions, and a systematic approach to complex case management. This 348-page practical resource bridges the gap between research literature and clinical application, offering experienced psychiatrists a structured approach to patients who haven't responded to conventional treatments. Effective tools for your most challenging cases. Inside this book, you'll find: A comprehensive framework for evaluating and defining treatment resistance, including diagnostic reconsideration and comorbidity assessment Evidence-based strategies for optimizing pharmacotherapy: augmentation, combination, and switching protocols backed by current research Practical guidance on advanced somatic treatments including ECT, TMS, ketamine/ esketamine, and emerging neuromodulation therapies Integration of psychotherapeutic approaches for treatment-resistant populations How to identify and address contributing factors: medical comorbidities, substance use, trauma, and medication interactions Pharmacogenomic testing and personalized medicine approaches: when to use them and how to interpret results Case studies illustrating decision-making in complex clinical scenarios Strategies for maintaining therapeutic alliance and managing patient and family expectations through prolonged treatment courses Updates on pipeline treatments and future directions in the field