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Is it possible to lower glycemia levels, even in the presence of adrenaline? The blockade of alpha-adrenergic receptors reveals a little explored field of research that promises to open up new therapeutic horizons useful in confronting the difficult and feared clinical situations of hyperglycemia.An experimental study, carried out in vivo , shows the effect of alpha-adrenergic blockade on glycemia levels in basal situations, in situations of stress, and even in a state of decrease in the number of pancreatic cells, in addition to comparing it in time and power, with the effect of insulin.